DelveInsight’s “Wilms Tumor Market Insights, Epidemiology, and Market Forecast-2030″ report delivers an in-depth understanding of the Wilms Tumor, historical and forecasted epidemiology as well as the Wilms Tumor market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.
Wilms’ tumor is an embryonal type of renal cancer, is one of the most common solid malignant neoplasms in children. It accounts for approximately 90% of all pediatric tumors of the kidney. The total number of new cases of Wilms’ tumor in the UK is estimated at 80 cases per year. The tumor usually arises in a single kidney. Synchronous bilateral or multifocal tumors occur in approximately 10% of patients and tend to present at an earlier age. Wilms’ tumor can also be diagnosed in adolescents or adults, but this is extremely rare, representing less than 1% of all renal tumors.
Some facts of the Wilms Tumor Market are:
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Wilms Tumor arises from nephrogenic rests, which are undifferentiated embryonic tissues retained after birth. At the molecular level, in a proportion of patients, WT is the result of aberrations in the WT1 gene, located on chromosome 11p13. In addition to being a risk factor for WT, germline WT1 aberrations can cause renal and extra-renal developmental abnormalities and predispose to other malignancies. In the past two decades, there has been a considerable improvement in our understanding of WT and WT1.
Within Wilms’ tumors there are three main types of tumor cells; blastema, resembling the undifferentiated embryonic metanephric mesenchyme, and thought to contain any tumor stem cells, together with epithelium, and stroma, both thought to have differentiated from the blastema. These cell types are distinguished histologically and currently, there are no good markers to specifically identify blastema. All three elements arenot required, however, to have a diagnosis of Wilms tumor.
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