Major Pharma giants are thoroughly working toward the development of new treatment therapies for this indication to provide better relief for the symptoms and hence improve the Quality of life (QoL) of patients with Hemophilia B. Currently, gene therapies are gaining popularity due to their potential to cure this disease and also the anticipated one-time infusion. Apart from this, increased focus on prophylactic treatment increased usage of extended half-life therapies, and anticipated entry of premium-priced novel hemophilia B treatments will also contribute to the market’s growth.
DelveInsight’s “Hemophilia B Market Insights, Epidemiology, and Market Forecast 2032” report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the Hemophilia B market size, share, trends, and growth opportunities in the seven major markets (7MM) (i.e., the United States, EU4 (Germany, Spain, Italy, France), the United Kingdom and Japan).
The Hemophilia B market report covers emerging drugs, current treatment practices, market share of individual therapies, and current & forecasted market size from 2019 to 2032. It also evaluates the current treatment practice/algorithm, key drivers & barriers impacting the market growth, and unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market.
Hemophilia B: An Overview
Hemophilia is defined as an inherited bleeding disorder in which the blood does not clot properly. This can lead to spontaneous bleeding and bleeding following injuries or surgery. It is caused by a gene defect that decides how factors VIII, IX, or XI are produced by the body. One of the Hemophilia types is Hemophilia B, also called factor IX (FIX) deficiency or Christmas disease, which is a genetic disorder caused by missing or defective factor IX, a clotting protein.
Although it is passed down from parents to children, about one-third of cases are caused by a spontaneous mutation, a change in a gene. Clotting factors are specialized proteins needed for blood clotting, the process by which blood seals a wound to stop bleeding and promote healing.
The two main symptoms are bleeding for longer than normal and bruising easily. Even a small bump on the head can be serious with this disease. Hemophilia B can range from mild to moderate to severe. Individuals with mild hemophilia have factor IX levels between 5 and 40% of normal; those with moderate hemophilia have factor levels from 1 to 5% of normal; and individuals with severe hemophilia have factor levels <1% of normal.
Hemophilia B Market Key Facts
Among the 7MM, the US accounts for ~50% of the overall market size of Hemophilia B in 2020.
Among the EU-5 countries, France accounts for the highest market size for Hemophilia B, followed by the United Kingdom
In the United States, the total number of prevalent cases of Hemophilia B was 4,134 in the year 2020, which is expected to grow during the study period.
In the year 2020, the total number of prevalent cases of Hemophilia B was 5,408 in EU5.
In Japan, the total number of prevalent cases of Hemophilia B was 1,198 in the year 2020.
Moderate and severe account for ~75% of the Hemophilia B patient pool. In the 7MM, there were around 8,054 moderate and severe Hemophilia B cases in 2020.
In the 7MM, approximately 5% of Hemophilia B cases develop inhibitors, i.e., 537 patients with inhibitors in 2020. In addition to this, 95% of the Hemophilia B cases were observed without inhibitors. The number of cases for both categories will increase during the study period.
Hemophilia B Market
The market outlook section of the report helps to build a detailed comprehension of the historical, current and forecasted Hemophilia B market size by analyzing the impact of current and emerging pipeline therapies. It also thoroughly assesses the market drivers & barriers, unmet needs, and emerging technologies set to impact the market dynamics.
The report gives complete detail of the Hemophilia B market trend for each marketed drug and mid & late-stage pipeline therapies by evaluating their impact based on the annual cost of therapy, their Mechanism of Action (MOA), Route of Administration (ROA), molecule types, competition with other therapies, brand value, and their impact on the market.
Hemophilia B Epidemiology Assessment
The epidemiology section provides insights into the historical, current, and forecasted epidemiology trends in the seven major countries (7MM) from 2019 to 2032. It helps to recognize the causes of current and forecasted epidemiology trends by exploring numerous studies and research. The epidemiology section also provides a detailed analysis of diagnosed and prevalent patient pool, future trends, and views of key opinion leaders.
The Report Covers the Hemophilia B Epidemiology, Segmented as –
Total Diagnosed Prevalent Pool of Hemophilia B [2019–2032]
Treated Prevalent Pool of Hemophilia B [2019–2032]
Severity-specific Prevalent Pool of Hemophilia B [2019–2032]
Prevalent population of Hemophilia B with or without Inhibitors [2019–2032]
Hemophilia B Drugs Uptake and Pipeline Development Activities
The drug uptake section focuses on the uptake rate of potential drugs recently launched in the Hemophilia B market or expected to be launched during the study period. The analysis covers the Hemophilia B market uptake by drugs, patient uptake by therapies, and sales of each drug. Moreover, the therapeutics assessment section helps understand the drugs with the most rapid uptake and the reasons behind the maximal use of the drugs. Additionally, it compares the drugs based on market share.
The report also covers the Hemophilia B pipeline development activities. It provides valuable insights about different therapeutic candidates in various stages and the key companies involved in developing targeted therapeutics. It also analyses recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.
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The Leading Companies in the Hemophilia B Therapeutics Market Include:
Alnylam Pharmaceuticals
ApcinteX Ltd
Bioverativ Therapeutics
CSL Behring
Freeline Therapeutics
Genzyme, a Sanofi Company
HEMA Biologics
LFB Pharmaceuticals
Novo Nordisk
Pfizer
Sangamo Therapeutics
Sobi
Spark Therapeutics
UniQure Biopharma B.V.
And Many Others
Hemophilia B Marketed and Emerging Therapies Covered in the Report Include:
Alprolix: Bioverativ Therapeutics/Sobi
Concizumab (NN7415): Novo Nordisk
Concizumab: Novo Nordisk
Etranacogene dezaparvovec (AMT-061): UniQure Biopharma B.V./ CSL Behring
Fidanacogene elaparvovec (SPK-9001/PF-06838435): Pfizer/Spark Therapeutics
Fitusiran: Genzyme, a Sanofi Company/ Alnylam Pharmaceuticals
FLT180a: Freeline Therapeutics
Idelvion: CSL Behring
Marstacimab (PF-06741086): Pfizer
Rebinyn (Nonacog beta pegol): Novo Nordisk
SB-FIX: Sangamo Therapeutics
SerpinPC: ApcinteX Ltd
Sevenfact (coagulation factor VIIa [recombinant]-jncw): HEMA Biologics/LFB Pharmaceuticals
Verbrinacogene setparvovec (FLT-180a): Freeline Therapeutics
And Many More
The Report Covers the In-depth Assessment of the Emerging Drugs & Key Companies. Download the Sample Report to Learn More @
Table of Content (TOC)
1. Key Insights
2. Executive Summary
3. Hemophilia B Competitive Intelligence Analysis
4. Hemophilia B Market Overview at a Glance
5. Hemophilia B Disease Background and Overview
6. Hemophilia B Patient Journey
7. Hemophilia B Epidemiology and Patient Population (In the US, EU5, and Japan)
8. Hemophilia B Treatment Algorithm, Current Treatment, and Medical Practices
9. Hemophilia B Unmet Needs
10. Key Endpoints of Hemophilia B Treatment
11. Hemophilia B Marketed Products
12. Hemophilia B Emerging Drugs and Latest Therapeutic Advances
13. Hemophilia B Seven Major Market Analysis
14. Attribute Analysis
15. Hemophilia B Market Outlook (In US, EU5, and Japan)
16. Hemophilia B Access and Reimbursement Overview
17. KOL Views on the Hemophilia B Market
18. Hemophilia B Market Drivers
19. Hemophilia B Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer
*The Table of Contents (TOC) is not exhaustive; the final content may vary. Refer to the sample report for the complete table of contents.
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About DelveInsight
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